CHRONIC NASAL HYPER-REACTIVITY (CURRENT CLASSIFICATIONS, CLINICAL PATTERN, DIAGNOSIS)

Cutaneous reactivity pattern and nasal smear cytology in patients with chronic rhinosinusitis with nasal polyps; is it associated with the course of the disease?

Background and Objectives: To determine the association of hyper-reactivity to environmental allergens and mucosal secretion cytology with the course of disease in patients with chronic rhinosinusitis and nasal polyps (CRSwNP). Methods: A cross sectional study was conducted at Tehran Clinic of Asthma and Allergy in 2016. Adult patients who earned the definite diagnosis of CRSwNP and were free o...

Peripheral blood neutrophil cytokine hyper-reactivity in chronic periodontitis.

Pro-inflammatory cytokine release (IL-8, IL-6, TNF-α, IL-1β) by peripheral blood neutrophils, isolated from periodontitis patients (before/after therapy) and matched controls, was determined after 18 h culture in the presence/absence of Escherichia coli LPS, opsonised Staphylococcus aureus, heat-killed Fusobacterium nucleatum and Porphyromonas gingivalis. All cultures demonstrated differences i...

Nonspecific hyper-reactivity and localized allergy: cause of discrepancy between skin prick and nasal provocation test.

OBJECTIVE Disagreement between results of skin prick test (SPT) and nasal provocation tests (NPT) causes difficulty in differential diagnosis of allergic rhinitis (AR) and nonallergic rhinitis (NAR). We hypothesized this discrepancy could be due to the nonspecific hyper-reactivity (NHR) and localized allergy of the nasal cavity. STUDY DESIGN Prospective pilot. SETTING Academic tertiary rhin...

Intestinal current measurement versus nasal potential difference measurements for diagnosis

Current concepts in therapy of chronic rhinosinusitis and nasal polyposis.

The exact pathophysiological mechanisms leading to chronic rhinosinusitis (CRS) still to a large extent remain obscure. However, recently there has been some progress in elucidating the etiology of nasal polyposis, especially regarding tissue eosinophilia as well as the role of aspirin intolerance and eicosanoid mediators. Endonasal sinus surgery has evolved to be the treatment of choice in CRS...